Lee said Felicity Huffman is the best actress of the bunch, and has managed to sell herself as both a "down to earth mom" as well as a glamorous star. But surprisingly, that's not who Lee thinks is poised take Hollywood by storm.

"If success is defined as working constantly, then I predict Kathryn Joosten (who plays Karen McCluskey) will be the busiest right off the bat," Lee added. "I believe she will outlast them all.  She's a relative newcomer in Hollywood, only getting her breakthrough role in "The West Wing," but she has the ability, and interesting personality, to play all sorts of characters. I would love to see her do something along the lines of her acerbic but wise character in 'The West Wing.' I don't think 'Housewives' utilized her skills to their deepest level."